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Gladstone Scientists Discover Drug Candidate for Alzheimer’s, Huntington’s disease

Promising early research from The Gladstone Institutes at the University of California, San Francisco:

Scientists at the Gladstone Institutes have identified a drug candidate that diminishes the effects of both Alzheimer’s disease and Huntington’s disease in animal models, offering new hope for patients who currently lack any medications to halt the progression of these two debilitating illnesses.

Gladstone Investigator Paul Muchowski, PhD, has identified a new compound called JM6 in experiments done in collaboration with an international team of researchers, and which are being published today in an online article in Cell. In laboratory tests involving mice genetically engineered to model one or the other of the two diseases, Dr. Muchowski’s team found that JM6 blocks kynurenine 3-monooxygenase (KMO), an enzyme that has long been speculated to play a role in neurodegenerative diseases.

Read the rest of the article:

http://www.gladstone.ucsf.edu/gladstone/site/publicaffairs/content/1/720

 

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